Hotels in Otay Mesa, San Diego

Mon 3/4
Fri 3/8

Search hundreds of travel sites at once for hotels in Otay Mesa

...and more

Let KAYAK do the searching

Save on your next stay

Search and compare hundreds of travel sites at once for hotels in Otay Mesa

We’re completely free to use – no hidden charges or fees

Best hotels in Otay Mesa (San Diego)

Most recommended Otay Mesa hotels

Show all
Holiday Inn Express & Suites San Diego Otay Mesa - San Diego - Pool
465 ﷼+
Free Wi-Fi
Pool
Air Conditioning
Quality Suites San Diego Otay Mesa - San Diego - Bedroom
Quality Suites San Diego Otay Mesa
6.6 Okay
Otay Mesa498 ﷼+
498 ﷼+
Parking
Free Wi-Fi
Pool
Air Conditioning

How much is a Otay Mesa hotel?

Here are our most popular & best value hotels

2 stars and below

Good to know

Low season

November

High season

April
Cheapest month to stay with an average 30% drop in price.
Most expensive month to stay with an average 52% rise in price.

When to book a hotel in Otay Mesa

Price per night / 3-star hotel. Prices are not fixed and may vary with time.
Average nightly price per month
Average nightly price

Top tips for finding a hotel deal in Otay Mesa

  • For the lowest prices, try to book your Otay Mesa hotel more than 90 days before your stay.
  • Not sure just how much there is to see and do in Otay Mesa? KAYAK users usually book their hotel here for 5 days.

FAQs when booking a hotel in Otay Mesa

  • What are the best hotels in Otay Mesa?

    Otay Mesa is a great part of San Diego to make your base. If you’re staying in Otay Mesa area then Quality Suites San Diego Otay Mesa, Holiday Inn Express & Suites San Diego Otay Mesa, and AAAmazing San Diego! Suite just for you/yours! are all recommended on KAYAK.

  • How much does a hotel in Otay Mesa (San Diego) cost?

    The average price for a hotel room in Otay Mesa is 517 ﷼ but our users have found deals for as low as 423 ﷼. However, hotel prices in Otay Mesa vary a lot depending on the type of hotel, the time of year and more factors.

Where to stay in Otay Mesa?

Our map will help you find the perfect hotel in Otay Mesa, San Diego by showing you the exact location of each hotel.